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Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosDamasceno, Jeziel D; Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosSilva, Gabriel LA; Department of Epidemiology of Microbial DiseasesTschudi, Christian; Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosTosi, Luiz RO.
  • Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosDamasceno, Jeziel D; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosDamasceno, Jeziel D. Ribeirão Preto. BR
  • Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosSilva, Gabriel LA; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosSilva, Gabriel LA. Ribeirão Preto. BR
  • Department of Epidemiology of Microbial DiseasesTschudi, Christian; Yale University. School of Public Health. Department of Epidemiology of Microbial DiseasesTschudi, Christian. New Haven. US
  • Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosTosi, Luiz RO; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular e Bioagentes PatogênicosTosi, Luiz RO. Ribeirão Preto. BR
Mem. Inst. Oswaldo Cruz ; 112(8): 572-576, Aug. 2017. graf
Article in English | LILACS | ID: biblio-1040575
ABSTRACT
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma brucei brucei / RNA / Repetitive Sequences, Nucleic Acid / Telomerase / Leishmania Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade de São Paulo/BR / Yale University/US

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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma brucei brucei / RNA / Repetitive Sequences, Nucleic Acid / Telomerase / Leishmania Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade de São Paulo/BR / Yale University/US