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Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
Laboratório de Virologia MolecularLima, Lyana Rodrigues Pinto; Laboratório de Virologia MolecularAraújo, Nathália Alves de; Laboratório de Hantaviroses e RickettsiosesGuterres, Alexandro; Laboratório de AIDS e Imunologia MolecularPilotto, José Henrique; Laboratório de Virologia MolecularNiel, Christian; Laboratório de Virologia MolecularPaula, Vanessa Salete de.
Affiliation
  • Laboratório de Virologia MolecularLima, Lyana Rodrigues Pinto; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia MolecularLima, Lyana Rodrigues Pinto. Rio de Janeiro. BR
  • Laboratório de Virologia MolecularAraújo, Nathália Alves de; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia MolecularAraújo, Nathália Alves de. Rio de Janeiro. BR
  • Laboratório de Hantaviroses e RickettsiosesGuterres, Alexandro; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e RickettsiosesGuterres, Alexandro. Rio de Janeiro. BR
  • Laboratório de AIDS e Imunologia MolecularPilotto, José Henrique; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia MolecularPilotto, José Henrique. Rio de Janeiro. BR
  • Laboratório de Virologia MolecularNiel, Christian; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia MolecularNiel, Christian. Rio de Janeiro. BR
  • Laboratório de Virologia MolecularPaula, Vanessa Salete de; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia MolecularPaula, Vanessa Salete de. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 113(12): e180328, 2018. tab, graf
Article in En | LILACS | ID: biblio-1040588
Responsible library: BR1.1
ABSTRACT
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
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Full text: 1 Index: LILACS Main subject: Herpes Genitalis / HIV Infections / HIV-1 / Herpesvirus 2, Human / Genes, Viral Type of study: Prognostic_studies Limits: Female / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2018 Type: Article
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Full text: 1 Index: LILACS Main subject: Herpes Genitalis / HIV Infections / HIV-1 / Herpesvirus 2, Human / Genes, Viral Type of study: Prognostic_studies Limits: Female / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2018 Type: Article