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Subcellular localisation of FLAG tagged enzymes of the dynamic protein S-palmitoylation cycle of Trypanosoma cruzi epimastigotes
Laboratório de Biologia CelularBatista, Cassiano Martin; Laboratório de Biologia CelularSaad, Felipe; Laboratório de Biologia CelularCeccoti, Stephane Pini Costa; Eger, Iriane; Laboratório de Biologia CelularSoares, Maurilio José.
  • Laboratório de Biologia CelularBatista, Cassiano Martin; Fundação Oswaldo Cruz-Fiocruz. Instituto Carlos Chagas. Laboratório de Biologia CelularBatista, Cassiano Martin. Curitiba. BR
  • Laboratório de Biologia CelularSaad, Felipe; Fundação Oswaldo Cruz-Fiocruz. Instituto Carlos Chagas. Laboratório de Biologia CelularSaad, Felipe. Curitiba. BR
  • Laboratório de Biologia CelularCeccoti, Stephane Pini Costa; Fundação Oswaldo Cruz-Fiocruz. Instituto Carlos Chagas. Laboratório de Biologia CelularCeccoti, Stephane Pini Costa. Curitiba. BR
  • Eger, Iriane; Universidade Estadual de Ponta Grossa. Departamento de Biologia Geral. Ponta Grossa. BR
  • Laboratório de Biologia CelularSoares, Maurilio José; Fundação Oswaldo Cruz-Fiocruz. Instituto Carlos Chagas. Laboratório de Biologia CelularSoares, Maurilio José. Curitiba. BR
Mem. Inst. Oswaldo Cruz ; 113(8): e180086, 2018. tab, graf
Article in English | LILACS | ID: biblio-1040598
ABSTRACT
Dynamic S-palmitoylation of proteins is the addition of palmitic acid by zDHHC palmitoyl transferases (PATs) and depalmitoylation by palmitoyl protein thioesterases (PPTs). A putative PAT (TcPAT1) has been previously identified in Trypanosoma cruzi, the etiological agent of Chagas disease. Here we analyse other 14 putative TcPATs and 2 PPTs in the parasite genome. T. cruzi cell lines expressing TcPATs and TcPPTs plus a FLAG tag at the C terminus were produced for most enzymes, with positive detection by indirect immunofluorescence. Overexpressed TcPATs were mostly found as single spots at the parasite anterior end, while the TcPPTs were dispersed throughout the parasite body.
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Full text: Available Index: LILACS (Americas) Main subject: Palmitates / Trypanosoma cruzi / Protozoan Proteins / Protein S / Lipoylation Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz-Fiocruz/BR / Universidade Estadual de Ponta Grossa/BR

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Full text: Available Index: LILACS (Americas) Main subject: Palmitates / Trypanosoma cruzi / Protozoan Proteins / Protein S / Lipoylation Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz-Fiocruz/BR / Universidade Estadual de Ponta Grossa/BR