Genomic analysis of bifunctional Class C-Class D ß-lactamases in environmental bacteria
Mem. Inst. Oswaldo Cruz
;
113(8): e180098, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1040602
ABSTRACT
β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.
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Index:
LILACS (Americas)
Main subject:
Beta-Lactamases
/
Catalytic Domain
/
Genomics
/
Environmental Microbiology
/
Gram-Negative Bacteria
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
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