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HIF-1α Levels in patients receiving chemoradiotherapy for locally advanced non-small cell lung carcinoma
Afsar, Cigdem Usul; Uysal, Pelin.
Affiliation
  • Afsar, Cigdem Usul; Acibadem Mehmet Ali Aydinlar University. Medical Faculty. Bakirkoy Acibadem Hospital. Istanbul. TR
  • Uysal, Pelin; Acibadem Mehmet Ali Aydinlar University. Medical Faculty. Atakent Acibadem Hospital. Istanbul. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);65(10): 1295-1299, Oct. 2019. tab, graf
Article in En | LILACS | ID: biblio-1041027
Responsible library: BR1.1
ABSTRACT
SUMMARY AIM To examine the relationship between treatment response and hypoxia-inducible factor-1 alpha (HIF-1α) levels in patients with locally advanced non-small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT). METHODS Eighty patients with NSCLC were included in the study and treated at Acibadem Mehmet Ali Aydınlar University Medical Faculty. HIF-1 α levels were measured before and after CRT by the enzyme-linked immunosorbent assay (ELISA) method. RESULTS Patients' stages were as follows; stage IIIA (65%) and stage IIIB (35%). Squamous histology was 45%, adenocarcinoma was 44%, and others were 11%. Chemotherapy and radiotherapy were given concurrently to 80 patients. Forty-five (56%) patients received cisplatin-based chemotherapy, and 35 (44%) received carboplatin-based chemotherapy. Serum HIF-1α levels (42.90 ± 10.55 pg/mL) after CRT were significantly lower than the pretreatment levels (63.10 ± 10.22 pg/mL, p<0.001) in patients with locally advanced NSCLC. CONCLUSION The results of this study revealed that serum HIF-1α levels decreased after CRT. Decrease of HIF-1α levels after the initiation of CRT may be useful for predicting the efficacy of CRT.
RESUMO
RESUMO OBJETIVO Examinar a relação entre a resposta ao tratamento e os níveis de fator 1 induzida por hipóxia (HIF-1α) em pacientes com câncer de pulmão de células não pequenas localmente avançado (NSCLC) que receberam quimiorradioterapia (CRT). MÉTODO Oitenta pacientes com NSCLC foram incluídos no estudo e foram tratados na Faculdade de Medicina da Acibadem Mehmet Ali Aydınlar University. O nível de HIF-1α foi medido antes e depois da TRC pelo método de ensaio imunoenzimático (ELISA). RESULTADOS Os estágios dos pacientes foram os seguintes; estágio IIIA (65%) e estágio IIIB (35%). A histologia escamosa foi de 45%, o adenocarcinoma de 44% e o outro de 11%. Quimioterapia e radioterapia foram dadas simultaneamente a 80 pacientes. Quarenta e cinco (56%) pacientes receberam quimioterapia à base de cisplatina e 35 (44%) receberam quimioterapia à base de carboplatina. Os níveis séricos de HIF-1α (42,90 ± 10,55 pg / mL) após a TRC foram significativamente menores do que os níveis pré-tratamento (63,10 ± 10,22 pg / mL, p <0,001) em pacientes com NSCLC localmente avançado. CONCLUSÃO Os resultados deste estudo revelaram que os níveis séricos de HIF-1α diminuíram após a TRC. A diminuição dos níveis de HIF-1α após o início da TRC pode ser útil para prever a eficácia da TRC.
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Full text: 1 Index: LILACS Main subject: Adenocarcinoma / Biomarkers, Tumor / Carcinoma, Non-Small-Cell Lung / Hypoxia-Inducible Factor 1, alpha Subunit / Lung Neoplasms Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male Language: En Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Year: 2019 Type: Article

Full text: 1 Index: LILACS Main subject: Adenocarcinoma / Biomarkers, Tumor / Carcinoma, Non-Small-Cell Lung / Hypoxia-Inducible Factor 1, alpha Subunit / Lung Neoplasms Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male Language: En Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Year: 2019 Type: Article