Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?
Rev. Assoc. Med. Bras. (1992)
;
65(9): 1155-1160, Sept. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041075
ABSTRACT
SUMMARY OBJECTIVE In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus. METHODS A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups. RESULTS Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group 4.85 (1.92) mg/dl) (p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017). CONCLUSION UA levels may be an important predictor of nephropathy in diabetic patients.
RESUMO
RESUMO OBJETIVO O objetivo deste estudo foi analisar a relação entre o ácido úrico sérico e a microalbuminúria como marcador de lesão renal no diabetes mellitus tipo 2. MÉTODOS Um total de 100 pacientes com diabetes mellitus tipo 2 foram inscritos no estudo. Os grupos de estudo foram divididos em dois, de acordo com a relação microalbumina/creatinina na urina nefropatia diabética e grupo não nefropático. UA e microalbuminúria foram comparados entre os grupos de estudo. RESULTADOS Os níveis séricos de AU de pacientes com nefropatia diabética foram significativamente maiores do que o grupo sem nefropatia (AU em pacientes com grupos de nefropatia diabética 6,3 (1,82) mg/dl, AU em pacientes com grupos não nefropáticos 4,85 (1,92) mg/dl ) (p<0,001). Houve correlação entre microalbuminúria e AU (r=0,238). Essa correlação foi estatisticamente significativa (p=0,017). CONCLUSÃO Os níveis de AU podem ser um importante preditor de nefropatia em pacientes diabéticos.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Uric Acid
/
Hyperuricemia
/
Diabetes Mellitus, Type 2
/
Diabetic Nephropathies
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2019
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Abant Izzet Baysal University Hospital/TR
Similar
MEDLINE
...
LILACS
LIS