Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C
Rev. Soc. Bras. Med. Trop
;
50(1): 113-116, Jan.-Feb. 2017. tab
Article
in English
| LILACS
| ID: biblio-1041392
ABSTRACT
Abstract INTRODUCTION:
Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis.METHODS:
RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression.RESULTS:
The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB.CONCLUSIONS:
A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.
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Index:
LILACS (Americas)
Main subject:
Platelet-Derived Growth Factor
/
Hepatitis C, Chronic
/
Proto-Oncogene Proteins c-sis
/
Transforming Growth Factor beta1
/
Liver Cirrhosis
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual Paulista Júlio de Mesquita Filho/BR
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