Evaluation of the commercial kit SIRE nitratase for detecting resistant mycobacterium tuberculosis in Brazil
Rev. Soc. Bras. Med. Trop
;
50(4): 550-553, July-Aug. 2017. tab
Article
in English
| LILACS
| ID: biblio-1041420
ABSTRACT
Abstract INTRODUCTION:
This study aimed to evaluate a new commercial kit, Kit SIRE Nitratase-PlastLabor, for testing the drug susceptibility of clinical Mycobacterium tuberculosis isolates.METHODS:
The accuracy of the Kit SIRE Nitratase was evaluated by examining the susceptibility (streptomycin, isoniazid, rifampicin, and ethambutol) of 40 M. tuberculosis isolates, using the proportion method with Lowenstein-Jensen medium or the BACTEC MGIT 960 system.RESULTS:
The detection accuracy for streptomycin, isoniazid, rifampicin, and ethambutol was 95%, 97.5%, 100%, and 80%, respectively.CONCLUSIONS:
The exceptional accuracy demonstrated by Kit SIRE Nitratase for isoniazid and rifampicin makes the kit an attractive option for screening M. tuberculosis strain resistance.
Full text:
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Index:
LILACS (Americas)
Main subject:
Oxidoreductases
/
Microbial Sensitivity Tests
/
Antibiotics, Antitubercular
/
Mycobacterium tuberculosis
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Ministério da Saúde/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal do Rio de Janeiro/BR
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