Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Rev. Soc. Bras. Med. Trop
;
50(5): 689-692, Sept.-Oct. 2017. graf
Article
in English
| LILACS
| ID: biblio-1041423
ABSTRACT
Abstract INTRODUCTION:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.METHODS:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.RESULTS:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.CONCLUSIONS:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
CD4-Positive T-Lymphocytes
/
Chagas Cardiomyopathy
/
CD8-Positive T-Lymphocytes
/
Receptors, CCR
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade Pernambucana da Saúde/BR
/
Fundação Oswaldo Cruz/BR
/
Universidade de Pernambuco/BR
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