Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
Rev. Soc. Bras. Med. Trop
;
51(1): 94-98, Jan.-Feb. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1041447
ABSTRACT
Abstract INTRODUCTION:
Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.METHODS:
Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.RESULTS:
Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.CONCLUSIONS:
BCG responsiveness does not affect protection against atopy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunoglobulin E
/
BCG Vaccine
/
Immunization, Secondary
/
Interferon-gamma
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
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