The relationship between atopy and neurological manifestations in HTLV-1 infection
Rev. Soc. Bras. Med. Trop
;
51(2): 207-211, Mar.-Apr. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1041456
ABSTRACT
Abstract INTRODUCTION:
Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses.METHODS:
Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers.RESULTS:
Atopic HAM/TSP patients with high IFN-γ production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders.CONCLUSIONS:
Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.
Full text:
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Index:
LILACS (Americas)
Main subject:
HTLV-I Infections
/
Hypersensitivity, Immediate
/
Nervous System Diseases
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Bahia/BR
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