Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits
Rev. Soc. Bras. Med. Trop
;
51(3): 382-386, Apr.-June 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1041466
ABSTRACT
Abstract INTRODUCTION This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. METHODS The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. RESULTS Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. CONCLUSIONS The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.
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Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Plant Extracts
/
Leishmania guyanensis
/
Piper
/
Fruit
/
Antiprotozoal Agents
Limits:
Humans
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Educação e Cultura de Vilhena/BR
/
Fundação Oswaldo Cruz/BR
/
Fundação Universidade Federal de Rondônia/BR
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