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Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Fernandes, Erica de Souza; Lorena, Virgínia Maria de Barros; Sales, Iana Rafaela Fernandes; Albuquerque, Mônica Camelo Pessoa de Azevedo; Gomes, Yara de Miranda; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de.
  • Fernandes, Erica de Souza; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife. BR
  • Lorena, Virgínia Maria de Barros; Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia. Recife. BR
  • Sales, Iana Rafaela Fernandes; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife. BR
  • Albuquerque, Mônica Camelo Pessoa de Azevedo; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife. BR
  • Gomes, Yara de Miranda; Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia. Recife. BR
  • Costa, Vlaudia Maria Assis; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife. BR
  • Souza, Valdênia Maria Oliveira de; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife. BR
Rev. Soc. Bras. Med. Trop ; 51(4): 546-549, July-Aug. 2018. graf
Article in English | LILACS | ID: biblio-1041472
ABSTRACT
Abstract

INTRODUCTION:

We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.

METHODS:

We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.

RESULTS:

BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.

CONCLUSIONS:

Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Antibodies, Helminth / Interleukin-2 / Interleukin-10 / T-Lymphocytes, Regulatory / Animals, Suckling Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Antibodies, Helminth / Interleukin-2 / Interleukin-10 / T-Lymphocytes, Regulatory / Animals, Suckling Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal de Pernambuco/BR