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Antiprotozoal action of synthetic cinnamic acid analogs
Santos, Ana Paula de Azevedo dos; Fialho, Saara Nery; Medeiros, Daniel Sol Sol de; Garay, Ana Fidelina Gómez; Diaz, Jorge Alfonso Ruiz; Gómez, Maria Celeste Vega; Teles, Carolina Bioni Garcia; Calderon, Leonardo de Azevedo.
  • Santos, Ana Paula de Azevedo dos; Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho. BR
  • Fialho, Saara Nery; Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho. BR
  • Medeiros, Daniel Sol Sol de; Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho. BR
  • Garay, Ana Fidelina Gómez; Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho. BR
  • Diaz, Jorge Alfonso Ruiz; Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho. BR
  • Gómez, Maria Celeste Vega; Centro para el Desarrollo de Investigación Científica. Asunción. PY
  • Teles, Carolina Bioni Garcia; Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho. BR
  • Calderon, Leonardo de Azevedo; Fundação Oswaldo Cruz. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho. BR
Rev. Soc. Bras. Med. Trop ; 51(6): 849-853, Nov.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-1041494
ABSTRACT
Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Trypanosoma cruzi / Cinnamates / Leishmania / Antiprotozoal Agents Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil / Paraguay Institution/Affiliation country: Centro para el Desarrollo de Investigación Científica/PY / Fundação Oswaldo Cruz/BR / Universidade Federal de Rondônia/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Trypanosoma cruzi / Cinnamates / Leishmania / Antiprotozoal Agents Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil / Paraguay Institution/Affiliation country: Centro para el Desarrollo de Investigación Científica/PY / Fundação Oswaldo Cruz/BR / Universidade Federal de Rondônia/BR