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Influence of antiretroviral therapy on bone metabolism of patients with chronic hepatitis B: a review
Dessordi, Renata; Santana, Rodrigo de Carvalho; Navarro, Anderson Marliere.
  • Dessordi, Renata; Universidade Estadual Paulista "Júlio de Mesquita Filho". Programa de Pós-Graduação Stricto Sensu em Alimentos e Nutrição. São Paulo. BR
  • Santana, Rodrigo de Carvalho; Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Ribeirão Preto. BR
  • Navarro, Anderson Marliere; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas do Estado de São Paulo. Departamento de Alimentos e Nutrição. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180441, 2019.
Article in English | LILACS | ID: biblio-1041501
ABSTRACT
Abstract Hepatitis B is a major public health problem worldwide and associated with significant mortality. To prevent or delay the deleterious effects of chronic infection by the hepatitis B virus, patients should be carefully followed, and antiviral therapy indicated according to specific recommendations. Currently, available drugs inhibit viral replication and slow or stop the progression of inflammation and fibrosis of the liver. However, the drugs for oral use in the treatment of hepatitis B, jointly referred to as nucleoside/nucleotide analogs, are indicated for prolonged use and have potential side effects. The reduction in bone mineral density was associated with the use of tenofovir, already evaluated in patients infected with HIV because the drug is also part of the therapeutic arsenal for this viral infection. There are few studies on the effects of tenofovir in patients with mono hepatitis B. Therefore, this literature review proposes to examine how hepatitis B acts in the body and the mechanisms by which antiretroviral drugs (especially tenofovir) can affect bone metabolism.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bone Density / Bone Remodeling / Hepatitis B, Chronic / Anti-Retroviral Agents Type of study: Practice guideline Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR / Universidade Estadual Paulista/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bone Density / Bone Remodeling / Hepatitis B, Chronic / Anti-Retroviral Agents Type of study: Practice guideline Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR / Universidade Estadual Paulista/BR / Universidade de São Paulo/BR