TGF-ß1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population
Rev. Soc. Bras. Med. Trop
;
52: e20170415, 2019. tab
Article
in English
| LILACS
| ID: biblio-1041504
ABSTRACT
Abstract INTRODUCTION:
Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL).METHODS:
Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay.RESULTS:
G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients.CONCLUSIONS:
G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Snake Bites
/
Snakes
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Maringá/BR
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