Emergence of aph(3')-VI and accumulation of aminoglycoside modifying enzyme genes in KPC-2-possessing Enterobacter aerogenes isolates from infections and colonization in patients from Recife-PE, Brazil
Rev. Soc. Bras. Med. Trop
;
52: e20180460, 2019. tab
Article
in English
| LILACS
| ID: biblio-1041512
ABSTRACT
Abstract INTRODUCTION:
The objective of this study was to characterize genes of aminoglycoside modifying enzymes (AMEs) in colonizing and infecting isolates of E. aerogenes harboring bla KPC from patients at a public hospital in Recife-PE, Brazil.METHODS:
We analyzed 29 E. aerogenes clinical isolates resistant to aminoglycosides. AMEs genes were investigated by PCR and sequencing.RESULTS:
Colonizing and infecting isolates mainly presented the genetic profiles aac(3)-IIa/aph(3')-VI or ant(2")-IIa/aph(3')-VI. This is the first report of aph(3')-VI in E. aerogenes harboring bla KPC in Brazil.CONCLUSIONS:
The results highlight the importance in establishing rigorous methods for the surveillance of resistance genes, especially in colonized patients.
Full text:
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Index:
LILACS (Americas)
Main subject:
Enterobacter aerogenes
/
Drug Resistance, Bacterial
/
Enterobacteriaceae Infections
/
Aminoglycosides
/
Anti-Bacterial Agents
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Ciências da Saúde/BR
/
Universidade Federal de Pernambuco/BR
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