Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
Rev. Soc. Bras. Med. Trop
;
52: e20190089B, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041519
ABSTRACT
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS:
Several virulence factors act in parallel in K. pneumoniae to impair host defense.
Full text:
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Index:
LILACS (Americas)
Main subject:
Phagocytosis
/
Virulence
/
Drug Resistance, Microbial
/
Virulence Factors
/
Klebsiella pneumoniae
/
Anti-Bacterial Agents
Limits:
Humans
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Ciências da Saúde de Alagoas/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de São Paulo/BR
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