Therapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria
Rev. Soc. Bras. Med. Trop
;
52: e20190163, 2019.
Article
in English
| LILACS
| ID: biblio-1041528
ABSTRACT
Abstract Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated malaria. Currently, there appears to be a downward trend in the efficacy of ACT in some parts of sub-Saharan Africa because some patients have been positive for Plasmodium parasite 3 days after artemether-lumefantrine treatment. We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Malaria, Falciparum
/
Artemether, Lumefantrine Drug Combination
/
Antimalarials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Nigeria
Institution/Affiliation country:
Bethel Faith Medical Centre/NG
/
Michael and Cecilia Ibru University/NG
/
University of Benin/NG
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