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Standardization of antigenemia and qpcr cut-off values in whole blood for the detection of cytomegalovirus disease in hiv patients
Carstensen, Suzana; Raboni, Sonia Mara; França, João Cesar Beenke; Teixeira, Francine.
  • Carstensen, Suzana; Universidade Federal do Paraná. Programa de Pós-graduação em Medicina Interna e Ciências da Saúde. Curitiba. BR
  • Raboni, Sonia Mara; Universidade Federal do Paraná. Programa de Pós-graduação em Medicina Interna e Ciências da Saúde. Curitiba. BR
  • França, João Cesar Beenke; Universidade Federal do Paraná. Divisão de Doenças Infecciosas. Curitiba. BR
  • Teixeira, Francine; Universidade Federal do Paraná. Divisão de Doenças Infecciosas. Curitiba. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180457, 2019. tab, graf
Article in English | LILACS | ID: biblio-1041557
ABSTRACT
Abstract

INTRODUCTION:

We defined the cut-off values of the antigenemia and cytomegalovirus (CMV) DNA tests in HIV/AIDS patients to identify CMV disease.

METHODS:

A total of 97 samples from 68 patients with and without CMV disease were analyzed by viral DNA detection and antigenemia assay.

RESULTS:

Qualitative and quantitative results significantly differed between assays. The cut-off values for the antigenemia and qPCR assays were 1.5 positive cells/200,000 leukocytes and 3.715 log/mL, respectively.

CONCLUSIONS:

Antigenemia and qPCR are suitable for monitoring CMV disease in HIV patients, however, the threshold values should be determined within the centers where the patients are monitored.
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Full text: Available Index: LILACS (Americas) Main subject: DNA, Viral / AIDS-Related Opportunistic Infections / Cytomegalovirus Infections / Cytomegalovirus Type of study: Diagnostic study / Observational study / Prognostic study / Qualitative research / Risk factors Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: DNA, Viral / AIDS-Related Opportunistic Infections / Cytomegalovirus Infections / Cytomegalovirus Type of study: Diagnostic study / Observational study / Prognostic study / Qualitative research / Risk factors Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR