Emergence of bla NDM-1 associated with the aac(6')-Ib-cr, acrB, cps, and mrkD genes in a clinical isolate of multi-drug resistant Klebsiella pneumoniae from Recife-PE, Brazil
Rev. Soc. Bras. Med. Trop
;
52: e20180352, 2019. tab
Article
in English
| LILACS
| ID: biblio-1041560
ABSTRACT
Abstract INTRODUCTION:
The emergence of New Delhi metallo-β-lactamase (NDM) is concernig because it reduces the antibiotic therapy options for bacterial infections.METHODS:
Resistant and virulent genes from an isolate of Klebsiella pneumoniae derived from a patient with sepsis in a hospital in Recife-PE, Brazil, were investigated using PCR and DNA sequencing.RESULTS:
bla NDM-1, aac(6')-Ib-cr and acrB resistance genes, and cps and mrkD virulence genes were detected. CONCLUSIONS To our knowledge, this is the first report on bla NDM-1 in Recife-PE. This detection alerts researchers to the need to control the spread of bla NDM-1 resistance gene by this bacterium in Brazil.
Full text:
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Index:
LILACS (Americas)
Main subject:
Bacterial Proteins
/
Virulence
/
Beta-Lactamases
/
Drug Resistance, Multiple, Bacterial
/
Klebsiella pneumoniae
/
Anti-Bacterial Agents
Type of study:
Risk factors
Limits:
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Pernambuco/BR
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