Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil
Rev. Soc. Bras. Med. Trop
;
52: e20180376, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041562
ABSTRACT
Abstract INTRODUCTION:
The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil.METHODS:
Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms.RESULTS:
Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found.CONCLUSIONS:
No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tumor Necrosis Factor-alpha
/
Meningitis, Cryptococcal
Type of study:
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Pará/BR
/
Universidade do Estado do Pará/BR
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