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Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
Vasconcelos, Nathalie Gaebler; Croda, Júlio; Silva, Késia Esther; Motta, Maria Lorenza Leal; Maciel, Wirlaine Glauce; Limiere, Letícia Cristina; Simionatto, Simone.
  • Vasconcelos, Nathalie Gaebler; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Croda, Júlio; Fundação Oswaldo Cruz. Campo Grande. BR
  • Silva, Késia Esther; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Motta, Maria Lorenza Leal; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Maciel, Wirlaine Glauce; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Limiere, Letícia Cristina; Universidade Federal da Grande Dourados. Hospital Universitário de Dourados. Dourados. BR
  • Simionatto, Simone; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180502, 2019. tab, graf
Article in English | LILACS | ID: biblio-1041563
ABSTRACT
Abstract

INTRODUCTION:

Plant products are sources for drug development against multidrug resistant bacteria. METHODS The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. RESULTS Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. CONCLUSIONS OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
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Full text: Available Index: LILACS (Americas) Main subject: Serratia marcescens / Oils, Volatile / Acinetobacter baumannii / Origanum / Gram-Negative Bacteria / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal da Grande Dourados/BR

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Full text: Available Index: LILACS (Americas) Main subject: Serratia marcescens / Oils, Volatile / Acinetobacter baumannii / Origanum / Gram-Negative Bacteria / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal da Grande Dourados/BR