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Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats
Loth, Eduardo Alexandre; Cecatto, Vanessa; Genske, Rodrigo Daniel; Costa, Maricília Silva; Gandra, Rinaldo Ferreira; Pilatti, Cleverson Marcelo.
  • Loth, Eduardo Alexandre; Universidade Estadual do Oeste do Paraná. Laboratório Experimental de Microbiologia e Análises Clínicas, Ensino, Pesquisa e Extensão. Cascavel. BR
  • Cecatto, Vanessa; Universidade Estadual do Oeste do Paraná. Laboratório Experimental de Microbiologia e Análises Clínicas, Ensino, Pesquisa e Extensão. Cascavel. BR
  • Genske, Rodrigo Daniel; Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos. BR
  • Costa, Maricília Silva; Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos. BR
  • Gandra, Rinaldo Ferreira; Universidade Estadual do Oeste do Paraná. Laboratório Experimental de Microbiologia e Análises Clínicas, Ensino, Pesquisa e Extensão. Cascavel. BR
  • Pilatti, Cleverson Marcelo; Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180043, 2019. graf
Article in English | LILACS | ID: biblio-1041578
ABSTRACT
Abstract

INTRODUCTION:

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.

METHODS:

Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.

RESULTS:

Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.

CONCLUSIONS:

Articular arthritic lesions were induced and progressed during the study period in all experimental groups.
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Full text: Available Index: LILACS (Americas) Main subject: Paracoccidioidomycosis / Arthritis, Experimental / Arthritis, Infectious Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Oeste do Paraná/BR / Universidade do Vale do Paraíba/BR

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Full text: Available Index: LILACS (Americas) Main subject: Paracoccidioidomycosis / Arthritis, Experimental / Arthritis, Infectious Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Oeste do Paraná/BR / Universidade do Vale do Paraíba/BR