Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Rev. Soc. Bras. Med. Trop
;
52: e20180225, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041579
ABSTRACT
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS:
We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil.RESULTS:
We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples.CONCLUSIONS:
Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.
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Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Drug Resistance
/
Protozoan Proteins
/
Malaria, Falciparum
/
Artemisinins
/
Mutation
Type of study:
Practice guideline
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
/
Portugal
Institution/Affiliation country:
Ministério da Saúde/BR
/
Universidade Federal de Fluminense/BR
/
Universidade Federal de Goiás/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade Nova de Lisboa/PT
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