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The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial
Sepaskhah, Mozhdeh; Behdad, Kasra; Bagheri, Zahra.
  • Sepaskhah, Mozhdeh; Shiraz University of Medical Sciences. Molecular Dermatology Research Center. Shiraz. IR
  • Behdad, Kasra; Shiraz University of Medical Sciences. Molecular Dermatology Research Center. Shiraz. IR
  • Bagheri, Zahra; Shiraz University of Medical Sciences. Department of Biostatistics. Shiraz. IR
Rev. Soc. Bras. Med. Trop ; 52: e20180278, 2019. tab, graf
Article in English | LILACS | ID: biblio-1041586
ABSTRACT
Abstract

INTRODUCTION:

The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.

METHODS:

For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response.

RESULTS:

Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week.

CONCLUSIONS:

Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Cutaneous / Cryotherapy / Gentian Violet / Anti-Infective Agents, Local Type of study: Controlled clinical trial / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Shiraz University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Cutaneous / Cryotherapy / Gentian Violet / Anti-Infective Agents, Local Type of study: Controlled clinical trial / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Shiraz University of Medical Sciences/IR