The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial
Rev. Soc. Bras. Med. Trop
;
52: e20180278, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041586
ABSTRACT
Abstract INTRODUCTION:
The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.METHODS:
For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response.RESULTS:
Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week.CONCLUSIONS:
Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.
Full text:
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Index:
LILACS (Americas)
Main subject:
Leishmaniasis, Cutaneous
/
Cryotherapy
/
Gentian Violet
/
Anti-Infective Agents, Local
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Shiraz University of Medical Sciences/IR
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