Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
Rev. Soc. Bras. Med. Trop
;
52: e20180001, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1041589
ABSTRACT
Abstract INTRODUCTION:
Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.METHODS:
Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.RESULTS:
Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.CONCLUSIONS:
These findings highlight the role of host stress in the virulence of S. epidermidis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Staphylococcus epidermidis
/
Virulence
/
Biofilms
/
Culture Media
/
Host Microbial Interactions
Limits:
Humans
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Goiás/BR
/
Universidade Federal de Mato Grosso do Sul/BR
/
Universidade de Brasília/BR
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