Adverse events in patients with leprosy on treatment with thalidomide
Rev. Soc. Bras. Med. Trop
;
52: e20180385, 2019. tab
Article
in English
| LILACS
| ID: biblio-1041594
ABSTRACT
Abstract INTRODUCTION:
Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.METHODS:
A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Odds ratios with 95% confidence intervals were estimated via logistic regression.RESULTS:
Peripheral neuropathy symptoms and deep vein thrombosis (DVT) were the most common AEs reported. Although women of reproductive age used contraceptives, <50% of patients reported using condoms. Polypharmacy was associated with all endpoints, except DVT.CONCLUSIONS:
Pharmacovigilance is crucial to prevent harmful thalidomide-associated AEs.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Thalidomide
/
Leprostatic Agents
/
Leprosy
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Ezequiel Dias/BR
/
Universidade Federal de Minas Gerais/BR
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