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Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014
Souza, Alex Junior Souza de; Malheiros, Andreza Pinheiro; Sarmento, Vânia Pinto; Resende, Fabricio de Souza; Alves, Max Moreira; Nunes, Heloisa Marceliano; Soares, Manoel do Carmo Pereira; Sá, Lilian Rose Marques de.
  • Souza, Alex Junior Souza de; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia. São Paulo. BR
  • Malheiros, Andreza Pinheiro; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Sarmento, Vânia Pinto; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Resende, Fabricio de Souza; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Alves, Max Moreira; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Nunes, Heloisa Marceliano; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Soares, Manoel do Carmo Pereira; Instituto Evandro Chagas. Seção de Hepatologia. Belém. BR
  • Sá, Lilian Rose Marques de; Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 52: e20180465, 2019. tab
Article in English | LILACS | ID: biblio-1041598
ABSTRACT
Abstract INTRODUCTION We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A-C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. METHODS Serum samples (n = 318) were tested using ELISA and immunoblotting, and screened for HEV-RNA by RT-qPCR. RESULTS Anti-HEV IgM and IgG were detected in 3.4% (11/318) and 5.9% (19/318) of the samples, respectively. All samples were HEV-RNA negative. CONCLUSIONS HEV was detected at a low prevalence. Broader serological and molecular evaluation of HEV infection in the Amazon region should be carried out.
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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis Antibodies / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Evandro Chagas/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis Antibodies / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Evandro Chagas/BR / Universidade de São Paulo/BR