The effect of high-dose vitamin c on biochemical markers of myocardial injury in coronary artery bypass surgery
Rev. bras. cir. cardiovasc
;
34(5): 517-524, Sept.-Oct. 2019. tab
Article
in English
| LILACS
| ID: biblio-1042055
ABSTRACT
Abstract Objective:
To evaluate the effect of high-dose vitamin C on cardiac reperfusion injury and plasma levels of creatine kinase-muscle/brain (CK-MB), troponin I, and lactate dehydrogenase (LDH) in patients undergoing coronary artery bypass grafting (CABG).Methods:
This is a double-blind randomized clinical trial study. Fifty patients (50-80 years old) who had CABG surgery were selected. The intervention group received 5 g of intravenous vitamin C before anesthesia induction and 5 g of vitamin C in cardioplegic solution. The control group received the same amount of placebo (normal saline). Arterial blood samples were taken to determine the serum levels of CK-MB, troponin I, and LDH enzymes. Left ventricular ejection fraction was measured and hemodynamic parameters were recorded at intervals.Results:
High doses of vitamin C in the treatment group led to improvement of ventricular function (ejection fraction [EF]) and low Intensive Care Unit (ICU) stay. The cardiac enzymes level in the vitamin C group was lower than in the control group. These changes were not significant between the groups in different time intervals (anesthesia induction, end of bypass, 6 h after surgery, and 24 h after surgery) for CK-MB, LDH, and troponin I. Hemodynamic parameters, hematocrit, potassium, urinary output, blood transfusion, arrhythmia, and inotropic support showed no significant difference between the groups.Conclusion:
Vitamin C has significantly improved the patients' ventricular function (EF) 72 h after surgery and reduced the length of ICU stay. No significant changes in cardiac biomarkers, including CK-MB, troponin I, and LDH, were seen over time in each group. IRCT code IRCT2016053019470N33
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ascorbic Acid
/
Myocardial Reperfusion Injury
/
Coronary Artery Bypass
/
Antioxidants
Type of study:
Controlled clinical trial
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Journal subject:
Cardiology
/
General Surgery
Year:
2019
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Shiraz University of Medical Sciences/IR
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