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Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology
Fernandes, Júlia M; Cunha, Lorena M; Azevedo, Eduardo Pereira; Lourenço, Estela M. G; Fernandes-Pedrosa, Matheus F; Zucolotto, Silvana M.
  • Fernandes, Júlia M; Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Laboratório de Farmacognosia. Natal. BR
  • Cunha, Lorena M; Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Laboratório de Farmacognosia. Natal. BR
  • Azevedo, Eduardo Pereira; Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Laboratório de Farmacotécnica. Natal. BR
  • Lourenço, Estela M. G; Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Laboratório de Farmacognosia. Natal. BR
  • Fernandes-Pedrosa, Matheus F; Universidade Federal do Rio Grande do Norte. Laboratório de Tecnologia e Biotecnologia Farmacêutica. Natal. BR
  • Zucolotto, Silvana M; Universidade Federal do Rio Grande do Norte. Departamento de Farmácia. Laboratório de Farmacognosia. Natal. BR
Rev. bras. farmacogn ; 29(4): 529-558, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1042286
ABSTRACT
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as " saião " or " coirama ". Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, pharmacology and toxicology of K. laciniata and B. pinnatum species. An extensive literature review was conducted in different scientific databases. Various chemical constituents have been identified in extracts from different parts of K. laciniata and B. pinnatum , being flavonoids the major compounds. They have been traditionally used to treat inflammation, microbial infection, pain, respiratory diseases, gastritis, ulcers, diabetes and cancer tumors. Non-clinical in vitro assays evaluated mainly the antimicrobial and antioxidant activities, while in vivo assays evaluated the leishmanicide, anti-inflammatory and immunomodulatory activities. Regarding toxicity, few studies have been conducted for the two species. The information reported in this work might contribute to the recognition of the importance of K. laciniata and B. pinnatum species, as well as to direct further studies. (AU)
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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Ethnopharmacology / Crassulaceae / Kalanchoe Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Ethnopharmacology / Crassulaceae / Kalanchoe Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR