Sensibilidad diagnóstica de electroforesis de proteínas y cadenas livianas libres séricas en gammapatías monoclonales / Diagnostic accuracy of serum protein electrophoresis and free light chain measurements for monoclonal gammopathies
Rev. méd. Chile
;
146(1): 64-67, ene. 2018. tab
Article
in Spanish
| LILACS
| ID: biblio-1043145
ABSTRACT
Background:
International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis.Aim:
To evaluate the sensibility of a simple screening panel (SPE + FLC). Material andMethods:
We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG).Results:
Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively.Conclusions:
We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Paraproteinemias
/
Blood Protein Electrophoresis
/
Immunoglobulin Light Chains
Type of study:
Diagnostic study
/
Practice guideline
/
Observational study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Argentina
/
Chile
Institution/Affiliation country:
Hospital del Salvador/CL
/
The Binding Site/AR
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