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Mean platelet volume in nasal polyps / Volumen medio de las plaquetas en los pólipos nasales
Aktas, G; Sit, M; Tekce, H; Alfelik, A; Savli, H; Simsek, T; Ozmen, E; Isci, AZ; Apuhan, T.
  • Aktas, G; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Sit, M; Abant Izzet Baysal University Hospital. Department of General Surgery. Bolu. TR
  • Tekce, H; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Alfelik, A; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Savli, H; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Simsek, T; Abant Izzet Baysal University Hospital. Department of Otolaryngology. Bolu. TR
  • Ozmen, E; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Isci, AZ; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Apuhan, T; Abant Izzet Baysal University Hospital. Department of Otolaryngology. Bolu. TR
West Indian med. j ; 62(6): 515-518, July 2013. tab
Article in English | LILACS | ID: biblio-1045689
ABSTRACT

BACKGROUND:

Many studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in haemostasis, tissue repairing and inflammation. However, to our knowledge, there are no reports in the literature that study the association between platelet parameters and nasal polyps. SUBJECTS AND

METHODS:

Forty-three patients with nasal polyps and forty-nine healthy controls were enrolled in the study, retrospectively. Laboratory data ofpatients with nasal polyp were obtained at the time of diagnosis.

RESULTS:

There were no statistically significant differences between the two groups in terms of white blood count, haemoglobin, haematocrit and platelet count. The mean platelet volume (MPV) value of the nasal polyp group was significantly lower than the control group (p = 0.025). Mean eosinophil count was significantly elevated in the nasal polyp group compared to the control group (p < 0.001).

CONCLUSIONS:

Reduction in MPV may be an indicator for nasal polyp formation. Further studies with a larger study population are needed to detect the possible correlation between eosinophil count and MPVvalues in patients with nasal polyps.
RESUMEN
ANTECEDENTES Muchos estudios en literatura señalan que las inflamaciones relacionadas con los pólipos nasales dependen en su mayoría de los eosinófilos y sus productos inflamatorios. Además de los eosinófilos, las plaquetas pueden jugar un papel en el desarrollo de los pólipos nasales. Las plaquetas participan en la hemostasia, la reparación de tejidos, y la inflamación. Sin embargo, que sepamos, la literatura existente no reporta estudios acerca de la asociación entre los parámetros de las plaquetas y los pólipos nasales. SUJETOS Y

MÉTODOS:

Cuarenta y tres pacientes con pólipos nasales y cuarenta y nueve controles sanos se inscribieron en el estudio, de forma retrospectiva. Se obtuvieron datos de laboratorio de los pacientes con pólipos nasales en el momento del diagnóstico.

RESULTADOS:

No se encontraron diferencias estadísticamente significativas entre los dos grupos en términos de glóbulos blancos, hemoglobina, hematocritos y conteo de plaquetas. El valor medio de las plaquetas (MPV) del grupo con pólipos nasales fue significativamente menor que el del grupo control (p = 0. 025). El conteo medio de eosinófilos fue significativamente elevado en el grupo con pólipos nasales en comparación con el grupo control (p < 0.001).

CONCLUSIONES:

La reducción de MPVpuede ser un indicador para la formación de pólipos nasales. Se necesitan estudios adicionales con una mayor población de estudio para detectar la posible correlación entre los valores de MPV y el conteo de eosinófilos en pacientes con pólipos nasales.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Nasal Polyps / Mean Platelet Volume Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Turkey Institution/Affiliation country: Abant Izzet Baysal University Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Nasal Polyps / Mean Platelet Volume Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Turkey Institution/Affiliation country: Abant Izzet Baysal University Hospital/TR