FRAX-based intervention and assessment thresholds in seven Latin American countries
Rev. med. Rosario
;
84(3): 137-137, sept.-dic. 2018.
Article
in English
| LILACS
| ID: biblio-1051217
ABSTRACT
Age-specific intervention and assessment thresholds were developed for seven Latin American countries. The intervention threshold ranged from 1.2% (Ecuador) to 27.5% (Argentina) at the age of 50 and 90 years, respectively. In the Latin American countries, FRAX offers a substantial advance for the detection of subjects at high fracture risk.INTRODUCTION:
Intervention thresholds are proposed using the Fracture Risk Assessment (FRAX) tool. We recommended their use to calculate the ten-year probability of fragility fracture (FF) in both, men and women with or without the inclusion of bone mineral density (BMD). The purpose of this study is to compute FRAX-based intervention and BMD assessment thresholds for seven Latin American countries in men and women ≥ 40 years.METHODS:
The intervention threshold (IT) was set at a 10-year probability of a major osteoporotic fracture (MOF) equivalent to a woman with a prior FF and a body mass index (BMI) equal to 25.0 kg/m2 without BMD or other clinical risk factors. The lower assessment threshold was set at a 10-year probability of a MOF in women with BMI equal to 25.0 kg/m2, no previous fracture and no clinical risk factors. The upper assessment threshold was set at 1.2 times the IT.RESULTS:
For the seven LA countries, the age-specific IT varied from 1.5 to 27.5% in Argentina, 3.8 to 25.2% in Brazil, 1.6 up to 20.0% in Chile, 0.6 to 10.2% in Colombia, 0.9 up to 13.6% in Ecuador, 2.6 to 20.0% in Mexico, and 0.7 up to 22.0% in Venezuela at the age of 40 and 90 years, respectively.CONCLUSIONS:
In the LA countries, FRAX-based IT offers a substantial advance for the detection of men and women at high fracture risk, particularly in the elderly. The heterogeneity of IT between the LA countries indicates that country-specific FRAX models are appropriate rather than a global LA model (AU)
Full text:
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Index:
LILACS (Americas)
Main subject:
Osteoporosis
/
Age Factors
/
Risk Assessment
/
Latin America
Type of study:
Controlled clinical trial
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Etiology study
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Prognostic study
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Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. med. Rosario
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Argentina
/
Australia
/
Brazil
/
Chile
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Colombia
/
Mexico
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United States
/
Venezuela
Institution/Affiliation country:
Catholic University of Australia/AU
/
Centro Paulista de Investigação Clinica/BR
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Centro de Endocrinología/AR
/
Centro de Reumatología y Ortopedia/CO
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Clínica de la Universidad de los Andes/CL
/
Hospital Argerich/AR
/
Hospital Infantil de México Federico Gomez/MX
/
Laredo Medical Center/US
/
Universidad de Carabobo/VE
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