Your browser doesn't support javascript.
loading
Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017
Herber, Silvani; Terra, Anna Pires; Silva, André Anjos da; Fraga, Lucas Rosa; Vianna, Fernanda Sales Luiz; Schwartz, Ida Vanessa Doederlein; Faccini, Lavínia Schuler; Friedrich, Luciana.
  • Herber, Silvani; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Medicina. Porto Alegre. BR
  • Terra, Anna Pires; Hospital de Clínicas de Porto Alegre (HCPA). Serviço de Genética Médica. Porto Alegre. BR
  • Silva, André Anjos da; Hospital de Clínicas de Porto Alegre (HCPA). Serviço de Informação Teratogenética (Siat). Porto Alegre. BR
  • Fraga, Lucas Rosa; Universidade Federal do Rio Grande do Sul (UFRGS). Departamento de Ciências da Saúde. Porto Alegre. BR
  • Vianna, Fernanda Sales Luiz; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Genética e Biologia Molecular. Porto Alegre. BR
  • Schwartz, Ida Vanessa Doederlein; Universidade Federal do Rio Grande do Sul (UFRGS). Programa de Pós-graduação em Medicina. Porto Alegre. BR
  • Faccini, Lavínia Schuler; Hospital de Clínicas de Porto Alegre (HCPA). Serviço de Genética Médica. Porto Alegre. BR
  • Friedrich, Luciana; Universidade Federal do Rio Grande do Sul (UFRGS). Departamento de Pediatria. Porto Alegre. BR
Clin. biomed. res ; 39(3): 200-208, 2019.
Article in English | LILACS | ID: biblio-1052965
ABSTRACT

Introduction:

Microcephaly is a clinical finding that can arise from congenital anomalies or emerge after childbirth. Maternal infections acquired during pregnancy can result in characteristic brain damage in the newborn (NB), which may be visible even in the fetal stage. To describe the epidemiological profile of newborns with reported microcephaly and diagnosed with congenital infections in the state of Rio Grande do Sul between 2015 and 2017.

Methods:

A cross-sectional study was carried out on data collected from the Public Health Event Registry as well as from medical records. The investigation included serologies for toxoplasmosis and rubella; polymerase chain reaction (PCR) for Zika virus (ZIKV) in the blood and cytomegalovirus in the urine; non-treponemal tests for syphilis; and brain imaging tests.

Results:

Of the 257 reported cases of microcephaly, 39 were diagnosed with congenital infections. Severe microcephaly was identified in 13 patients (33.3%) and 51.3% of the cases showed alterations in brain imaging tests. In relation to the diagnosis of congenital infections, three patients (7.7%) were diagnosed with ZIKV, nine (23.1%) with cytomegalovirus, nine (23.1%) with toxoplasmosis, and 18 (46.1%) with congenital syphilis. The three cases of ZIKV showed calcification in brain imaging tests, signs of arthrogryposis, excess occipital skin and irritability, characterizing the typical phenotype of ZIKV infection.

Conclusions:

Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Zika Virus / Microcephaly Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Infant, Newborn Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre (HCPA)/BR / Universidade Federal do Rio Grande do Sul (UFRGS)/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Zika Virus / Microcephaly Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Infant, Newborn Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre (HCPA)/BR / Universidade Federal do Rio Grande do Sul (UFRGS)/BR