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Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle
Pokorska, Joanna; Piestrzynska-Kajtoch, Agata; Kulaj, Dominika; Ochrem, Andrzej; Radko, Anna.
  • Pokorska, Joanna; University of Agriculture in Krakow. Institute of Animal Science. Department of Cattle Breeding. Krakow. PL
  • Piestrzynska-Kajtoch, Agata; The National Research Institute of Animal Production. Department of Animal Molecular Biology. Balice. PL
  • Kulaj, Dominika; University of Agriculture in Krakow. Institute of Animal Science. Department of Cattle Breeding. Krakow. PL
  • Ochrem, Andrzej; University of Agriculture in Krakow. Institute of Animal Science. Department of Cattle Breeding. Krakow. PL
  • Radko, Anna; The National Research Institute of Animal Production. Department of Animal Molecular Biology. Balice. PL
Electron. j. biotechnol ; 40: 17-21, July. 2019. tab, ilus
Article in English | LILACS | ID: biblio-1053211
ABSTRACT

Background:

Mastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of innate immune response, which could be helpful in selecting cows with improved immunity to mastitis. Lipocalin-2 (LCN2) is a protein involved in the response of the immune system by eliminating iron ions which are necessary for the growth of pathogenic bacteria, so LCN2 may be considered as a natural bacteriostatic agent and could become a marker of infection.

Results:

A total of five SNPs were identified in LCN2 gene (one in the promoter, three in exon 1, and one in intron 1). A single haplotype block was identified. The locus g.98793763GNC was found to have a significant impact on protein levels in milk, and alleles of this locus were identified to have a significant positive dominance effect on this trait. None of the four analysed loci had a statistically significant impact on the milk yield, fat levels in milk or the somatic cell score. LCN-2 gene had no significant impact on the incidence of mastitis in the cows.

Conclusions:

Although the identified SNPs were not found to have any impact on the somatic cell count or the incidence of mastitis in cows, it seems that further research is necessary, covering a larger population of cattle, to confirm the association between lipocalin-2 and milk production traits and mastitis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Milk / Lipocalin-2 / Mastitis, Bovine Limits: Animals Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2019 Type: Article Affiliation country: Poland Institution/Affiliation country: The National Research Institute of Animal Production/PL / University of Agriculture in Krakow/PL

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Milk / Lipocalin-2 / Mastitis, Bovine Limits: Animals Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2019 Type: Article Affiliation country: Poland Institution/Affiliation country: The National Research Institute of Animal Production/PL / University of Agriculture in Krakow/PL