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The effect of Allium sativum in experimental peritoneal adhesion model in rats
Topal, Uğur; Göret, Nuri Emrah; Göret, Ceren Canbey; Özkan, Ömer Faruk.
  • Topal, Uğur; Erciyes University Medical Faculty. Department of General Surgery. Kayseri. TR
  • Göret, Nuri Emrah; Health Sciences University. Kartal Dr Lütfi Kırdar Research and Education Hospital. Department of General Surgery. Istanbul. TR
  • Göret, Ceren Canbey; Health Sciences University. Sancaktepe Research and Education Hospital. Department of Surgical Pathology. Istanbul. TR
  • Özkan, Ömer Faruk; Health Sciences University. Umraniye Research and Education Hospital. Department of General Surgery. Istanbul. TR
Acta cir. bras ; 34(10): e201901002, Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1054669
ABSTRACT
Abstract

Purpose:

To evaluate the effect of garlic on formation of postoperative adhesions in rats.

Methods:

Twenty-four Sprague dawley rats were divided into three groups. In Group 1 (sham), laparotomy was performed and stitched up. In Group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and 2 cc of saline was intraperitoneally administered to each rat. In Group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Allium sativum derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum

Results:

In Group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3.

Conclusions:

No positive outcomes indicating that Allium sativum reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, allium sativum increased the production of free oxygen radicals in the tissue.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Peritoneal Diseases / Garlic Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Erciyes University Medical Faculty/TR / Health Sciences University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Peritoneal Diseases / Garlic Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Erciyes University Medical Faculty/TR / Health Sciences University/TR