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Chorioallantoic urothelial tumor avatar. A clinical tool for phenotype-based therapy
Ossick, Marina Vian; Ferrari, Karen Linares; Nunes-Silva, Igor; Denardi, Fernandes; Reis, Leonardo Oliveira.
  • Ossick, Marina Vian; Universidade de Campinas. School of Medical Sciences. Department of Urology. BR
  • Ferrari, Karen Linares; UNICAMP. School of Medical Sciences. Department of Urology. Campinas. BR
  • Nunes-Silva, Igor; Instituto do Câncer Arnaldo Vieira de Carvalho. Department of Urology. Sao Paulo. BR
  • Denardi, Fernandes; UNICAMP. School of Medical Sciences. Department of Urology. Campinas. BR
  • Reis, Leonardo Oliveira; UNICAMP. School of Medical Sciences. Department of Urology. BR
Acta cir. bras ; 34(12): e201901207, 2019. graf
Article in English | LILACS | ID: biblio-1054689
Responsible library: BR1.1
ABSTRACT
Abstract In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. late cystectomy with unnecessary NAC adverse events) with potential to survival improvements, preclinical models of urothelial carcinoma have arisen in this generation as a way to pre-determine drug resistance even before therapy is targeted. The implantation of tumor specimens in the chorioallantoic membrane (MCA) of the chicken embryo results in a high-efficiency graft, thus allowing large-scale studies of patient-derived "tumor avatar". This article discusses a novel approach that exploits cancer multidrug resistance to provide personalized phenotype-based therapy utilizing the MIBC NAC dilemma.
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Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma / Urothelium / Chorioallantoic Membrane / Neoplasms, Experimental Limits: Animals / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto do Câncer Arnaldo Vieira de Carvalho/BR / UNICAMP/BR / Universidade de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma / Urothelium / Chorioallantoic Membrane / Neoplasms, Experimental Limits: Animals / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto do Câncer Arnaldo Vieira de Carvalho/BR / UNICAMP/BR / Universidade de Campinas/BR