Pyoderma gangrenosum: a review with special emphasis on Latin America literature
An. bras. dermatol
;
94(6): 729-743, Nov.-Dec. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1054881
ABSTRACT
Abstract Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pyoderma Gangrenosum
Type of study:
Diagnostic study
/
Prevalence study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2019
Type:
Article
Affiliation country:
Brazil
/
Peru
/
United States
Institution/Affiliation country:
Instituto de Evaluación de Tecnologías Sanitarias/PE
/
Oregon Health and Sciences University/US
/
Universidade Federal de Minas Gerais/BR
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