Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?
An. bras. dermatol
; 94(6): 713-716, Nov.-Dec. 2019. tab, graf
Article
in En
| LILACS
| ID: biblio-1054898
Responsible library:
BR1.1
ABSTRACT
Abstract Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year-old girl with cutaneous ulcers comparable with pyoderma gangrenosum, growth failure and chronic anemia, who was given the diagnosis of hyperzincemia and hypercalprotectinemia. Measurement of serum zinc and calprotectin concentrations are indicated in these cases.
Key words
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Index:
LILACS
Main subject:
Pyoderma Gangrenosum
/
Metal Metabolism, Inborn Errors
Limits:
Female
/
Humans
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2019
Type:
Article