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The role of NMDA receptor antagonists, amantadine and memantine, in schizophrenia treatment: a systematic review
JUNHO, BRUNO TERRA; OLIVEIRA, VICTOR FERNANDES DE.
  • JUNHO, BRUNO TERRA; Faculty of Medical Sciences of Minas Gerais. Department of Mental Health. Belo Horizonte. BR
  • OLIVEIRA, VICTOR FERNANDES DE; University of São Paulo. School of Pharmaceutical Sciences. Department of Clinical and Toxicological Analyses. São Paulo. BR
Arch. Clin. Psychiatry (Impr.) ; 46(6): 165-168, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1054913
ABSTRACT
Abstract Objective Schizophrenia is a complex and chronic psychiatric disorder. In recent years, studies have found glutamatergic system participation in its etiopathogenesis, especially through aberrant NMDA receptors functioning. Thus, drugs that modulate this activity, as amantadine and memantine, could theoretically be used in its treatment. To perform a systematic literature review about memantine and amantadine use as adjunct in schizophrenia treatment. Methods A systematic review of papers published in English indexed in the electronic database PubMed ® using the terms "memantine", "amantadine" and "schizophrenia" published until October 2016. Results We found 144 studies, 8 selected for analysis due to meet the objectives of this review. Some of these have shown benefits from such drug use, especially in symptoms measured by PANSS and its subdivisions, while others do not.

Discussion:

The data in the literature about these drugs use for schizophrenia treatment is still limited and have great heterogeneity. Thus, assay with greater robustness are needed to assess real benefits of these drugs as adjuvant therapy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Amantadine / Memantine / Receptors, N-Methyl-D-Aspartate Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: English Journal: Arch. Clin. Psychiatry (Impr.) Journal subject: Psychiatry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medical Sciences of Minas Gerais/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Amantadine / Memantine / Receptors, N-Methyl-D-Aspartate Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: English Journal: Arch. Clin. Psychiatry (Impr.) Journal subject: Psychiatry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medical Sciences of Minas Gerais/BR / University of São Paulo/BR