Growth hormone in the tumor microenvironment
Arch. endocrinol. metab. (Online)
;
63(6): 568-575, Nov.-Dec. 2019. graf
Article
in English
| LILACS
| ID: biblio-1055025
ABSTRACT
ABSTRACT Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6)568-75
Full text:
Available
Index:
LILACS (Americas)
Main subject:
DNA Damage
/
Drug Resistance, Neoplasm
/
Human Growth Hormone
/
Epithelial-Mesenchymal Transition
/
Tumor Microenvironment
/
Neovascularization, Pathologic
Limits:
Humans
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2019
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Cedars-Sinai Medical Center/US
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