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Correlation between CSF biomarkers of Alzheimer's disease and global cognition in a psychogeriatric clinic cohort
Radanovic, Márcia; Oshiro, Carlos A; Freitas, Thiago Q; Talib, Leda L; Forlenza, Orestes V.
  • Radanovic, Márcia; Universidade de São Paulo (USP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Oshiro, Carlos A; Universidade de São Paulo (USP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Freitas, Thiago Q; Universidade de São Paulo (USP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Talib, Leda L; Universidade de São Paulo (USP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Forlenza, Orestes V; Universidade de São Paulo (USP). Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 41(6): 479-484, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1055343
ABSTRACT

Objective:

The relationship between biomarkers of amyloid-beta aggregation (Aβ1-42) and/or neurodegeneration (Tau protein) in cerebrospinal fluid (CSF) and cognitive decline is still unclear. We aimed to ascertain whether CSF biomarkers correlate with cognitive performance in healthy and cognitively impaired subjects, starting from clinical diagnoses.

Methods:

We tested for correlation between CSF biomarkers and Mini-Mental State Examination (MMSE) scores in 208

subjects:

54 healthy controls, 82 with mild cognitive impairment (MCI), 46 with Alzheimer's disease (AD), and 26 with other dementias (OD).

Results:

MMSE correlated weakly with all CSF biomarkers in the overall sample (r = 0.242, p < 0.0006). Aβ1-42 and MMSE correlated weakly in MCI (r = 0.247, p = 0.030), and moderately in OD (r = 0.440, p = 0.027). t-Tau showed a weak inverse correlation with MMSE in controls (r = -0.284, p = 0.043) and MCI (r = -0.241, p = 0.036), and a moderate/strong correlation in OD (r = 0.665), p = 0.0003). p-Tau correlated weakly with MMSE in AD (r = -0.343, p = 0.026) and moderately in OD (r = -0.540, p = 0.0005). The Aβ1-42/p-Tau ratio had a moderate/strong correlation with MMSE in OD (r = 0.597, p = 0.001).

Conclusion:

CSF biomarkers correlated best with cognitive performance in OD. t-Tau correlated weakly with cognition in controls and patients with MCI. In AD, only p-Tau levels correlated with cognitive performance. This pattern, which has been reported previously, seems to indicate that CSF biomarkers might not be reliable as indicators of disease severity.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Amyloid beta-Peptides / Tau Proteins / Alzheimer Disease / Cognitive Dysfunction Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Amyloid beta-Peptides / Tau Proteins / Alzheimer Disease / Cognitive Dysfunction Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR