Incidence of depression in patients with hepatitis C treated with direct-acting antivirals
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(1): 72-76, Jan.-Feb. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1055367
ABSTRACT
Objective:
Depression has been associated with hepatitis C, as well as with its treatment with proinflammatory cytokines (i.e., interferon). The new direct-acting antiviral agents (DAAs) have minimal adverse effects and high potency, with a direct inhibitory effect on non-structural viral proteins. We studied the incidence and associated factors of depression in a real-life prospective cohort of chronic hepatitis C patients treated with the new DAAs.Methods:
The sample was recruited from a cohort of 91 patients with hepatitis C, of both sexes, with advanced level of fibrosis and no HIV coinfection, consecutively enrolled during a 6-month period for DAA treatment; those euthymic at baseline (n=54) were selected. All were evaluated through the depression module of the Patient Health Questionnaire (PHQ-9-DSM-IV), at three time points baseline, 4 weeks, and end-of-treatment.Results:
The cumulative incidence (95%CI) of major depression and any depressive disorder during DAA treatment was 13% (6.4-24.4) and 46.3% (33.7-59.4), respectively. No differences were observed between those patients with and without cirrhosis or ribavirin treatment (p > 0.05). Risk factors for incident major depression during DAA treatment included family depression (relative risk 9.1 [1.62-51.1]), substance use disorder (11.0 [1.7-73.5]), and baseline PHQ-9 score (2.1 [1.1-3.1]).Conclusions:
The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antiviral Agents
/
Hepatitis C
/
Depressive Disorder
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2020
Type:
Article
Affiliation country:
Spain
Institution/Affiliation country:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)/ES
/
Hospital Clínic de Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Universitat de Barcelona/ES
Similar
MEDLINE
...
LILACS
LIS