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Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages
Department of Animal ScienceMichelotto, Pedro Vicente; Department of Animal ScienceBastos, Fernanda Zettel; Department of Animal ScienceBarussi, Fernanda Cristina Mendes; Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina; Nishiyama, Anita.
  • Department of Animal ScienceMichelotto, Pedro Vicente; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceMichelotto, Pedro Vicente. Curitiba. BR
  • Department of Animal ScienceBastos, Fernanda Zettel; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceBastos, Fernanda Zettel. Curitiba. BR
  • Department of Animal ScienceBarussi, Fernanda Cristina Mendes; Pontifical Catholic University. School of Life Sciences. Department of Animal ScienceBarussi, Fernanda Cristina Mendes. Curitiba. BR
  • Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina; Pontifical Catholic University. School of Medicine. Laboratory for Experimental Cell CultureSenegaglia, Alexandra Cristina. Curitiba. BR
  • Nishiyama, Anita; Federal University of Paraná. Department of Physiology. Curitiba. BR
Braz. arch. biol. technol ; 62: e19180362, 2019. graf
Article in English | LILACS | ID: biblio-1055420
ABSTRACT
Abstract Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses. The present pilot study, shows that mesenchymal stromal cells can modulate alveolar macrophage function in asthma, interfering in the activity of PAF, being another potential pathway for mesenchymal stromal cells benefits in asthma.
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Full text: Available Index: LILACS (Americas) Main subject: Asthma / Platelet Activating Factor / Cell- and Tissue-Based Therapy / Horses Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR / Pontifical Catholic University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Asthma / Platelet Activating Factor / Cell- and Tissue-Based Therapy / Horses Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR / Pontifical Catholic University/BR