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Distribution of dendritic cells in aids-associated oral kaposi's sarcoma
Cáceres, Cinthia Veronica Bardalez Lopez de; Vargas, Pablo Agustin; Sánchez-Romero, Celeste; Bunn, Belinda K; Heerden, Willie F. P. van; Fonseca, Felipe Paiva.
  • Cáceres, Cinthia Veronica Bardalez Lopez de; Universidade de Campinas. Department of Oral Diagnosis. Piracicaba. BR
  • Vargas, Pablo Agustin; Universidade de Campinas. Department of Oral Diagnosis. Piracicaba. BR
  • Sánchez-Romero, Celeste; Universidade de Campinas. Department of Oral Diagnosis. Piracicaba. BR
  • Bunn, Belinda K; University of Pretoria. School of Dentistry, Faculty of Health Sciences. Department of Oral Pathology and Oral Biology. Pretoria. ZA
  • Heerden, Willie F. P. van; University of Pretoria. School of Dentistry, Faculty of Health Sciences. Department of Oral Pathology and Oral Biology. Pretoria. ZA
  • Fonseca, Felipe Paiva; Universidade de Campinas. Department of Oral Diagnosis. Piracicaba. BR
Braz. dent. j ; 30(6): 617-625, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1055455
ABSTRACT
Abstract The aim of this study was to determine if the distribution of Langerhans cells (LC) and interstitial dendritic cells (IDC) is altered in AIDS-associated oral Kaposi's sarcoma when compared to HIV-negative highly vascular oral lesions. Fifty-one cases of AIDS-associated oral Kaposi's sarcoma and 20 of highly vascular oral lesions were retrospectively retrieved. All cases of Kaposi's sarcoma were confirmed with immunoreactions against CD34 and HHV-8. Clinical data regarding sex, age and lesions location were obtained from pathology reports. Immunohistochemistry against CD207 (immature dendritic cells) and CD83 (mature dendritic cells) were done. LC were in the epithelium and IDC in the stroma. CD207+ cells predominated in the epithelium of the lesions, whereas CD83+ cells predominated in their stromal compartment. Kaposi's sarcoma had a lower CD207+ immature LC count (p=0.02) and an increased CD207+ IDC than highly vascular oral lesions (p<0.001). Moreover, Kaposi's sarcoma also showed an increased number of mature CD83+ IDC than highly vascular oral lesions (p<0.001). There were significant alterations in the distribution of LC and IDC in AIDS-associated Kaposi's sarcoma when compared to HIV-negative vascular oral lesions, suggesting that changes in their concentrations may play a role in the pathogenesis of Kaposi's sarcoma.
RESUMO
Resumo O objetivo deste estudo foi determinar se a distribuição das células de Langerhans (CL) e das células dendríticas intersticiais (CDI) está alterada no sarcoma de Kaposi oral associado à AIDS quando comparado às lesões orais altamente vasculares HIV-negativas. 51 casos de sarcoma de Kaposi oral associado à AIDS e 20 de lesões orais altamente vasculares foram recuperados retrospectivamente. Todos os casos de sarcoma de Kaposi foram confirmados pela positividade para os anticorpos CD34 e HHV-8. Dados clínicos sobre sexo, idade e localização das lesões foram obtidos dos laudos histopatológicos. Foram realizadas imunoistoquímica contra CD207 (células dendríticas imaturas) e CD83 (células dendríticas maduras). As CL estavam presentes no epitélio enquanto as CDI estavam presentes no estroma. As células CD207+ predominaram no epitélio das lesões, enquanto as células CD83+ predominaram no estroma. O sarcoma de Kaposi teve uma contagem mais baixa de CD imaturas CD207+ (p = 0,02) e número aumentado de CDC CD207+ do que lesões orais altamente vasculares (p<0,001). Além disso, o sarcoma de Kaposi também mostrou um número aumentado de CDI CD83+ maduras do que lesões orais altamente vasculares (p<0,001). Houve alterações significativas na distribuição de CL e CDI no sarcoma de Kaposi associado à AIDS quando comparado às lesões orais vasculares HIV-negativas, sugerindo que alterações na distribuição das mesmas podem desempenhar um papel na patogênese do sarcoma de Kaposi.
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Full text: Available Index: LILACS (Americas) Main subject: Sarcoma, Kaposi / Acquired Immunodeficiency Syndrome / Herpesvirus 8, Human Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil / South Africa Institution/Affiliation country: Universidade de Campinas/BR / University of Pretoria/ZA

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Full text: Available Index: LILACS (Americas) Main subject: Sarcoma, Kaposi / Acquired Immunodeficiency Syndrome / Herpesvirus 8, Human Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil / South Africa Institution/Affiliation country: Universidade de Campinas/BR / University of Pretoria/ZA