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Insulin resistance is associated with Sfrp5 in obstructive sleep apnea / Resistência à insulina está associada à Sfrp5 na apneia obstrutiva do sono
Sun, Shibo; Zhai, Huifen; Zhu, Mei; Wen, Peili; He, Xin; Wang, Haoyan.
  • Sun, Shibo; Beijing Friendship Hospital. Capital Medical University. Department of Respiratory Medicine. Beijing. CN
  • Zhai, Huifen; Beijing Friendship Hospital. Capital Medical University. Department of Respiratory Medicine. Beijing. CN
  • Zhu, Mei; Capital Medical University. Beijing Friendship Hospital. Department of Otolaryngological Medicine. Beijing. CN
  • Wen, Peili; Beijing Friendship Hospital. Capital Medical University. Department of Respiratory Medicine. Beijing. CN
  • He, Xin; Beijing Friendship Hospital. Capital Medical University. Department of Respiratory Medicine. Beijing. CN
  • Wang, Haoyan; Beijing Friendship Hospital. Capital Medical University. Department of Respiratory Medicine. Beijing. CN
Braz. j. otorhinolaryngol. (Impr.) ; 85(6): 739-745, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1055502
ABSTRACT
Abstract

Introduction:

Obstructive sleep apnea, a common disease, is usually complicated by insulin resistance and type 2 diabetes mellitus. Adipokine is considered to play an important role in the development of insulin resistance and type 2 diabetes mellitus in obstructive sleep apnea.

Objective:

To assess whether secreted frizzled-related protein 5, a new adipokine, is involved in untreated obstructive sleep apnea patients.

Methods:

Seventy-six subjects with obstructive sleep apnea and thirty-three control subjects without obstructive sleep apnea were recruited and matched in terms of body mass index and age. The fasting secreted frizzled-related protein 5 plasma concentration was tested using ELISA. In addition, the correlation between secreted frizzled-related protein 5 and the homeostasis model assessment of insulin resistance was obtained. Multiple linear regression analysis models with stepwise selection were performed to determine the independent associations between various factors and secreted frizzled-related protein 5.

Results:

Plasma secreted frizzled-related protein 5 levels were significantly lower in the obstructive sleep apnea group than in the control group (obstructive sleep apnea group 28.44 ± 13.25 ng/L; control group 34.16 ± 13.51 ng/L; p = 0.023). In addition, secreted frizzled-related protein 5 was negatively correlated with homeostasis model assessment of insulin resistance but positively correlated with the mean and lowest oxygen saturation with or without adjusting for age, gender, body mass index, neck circumference, waist circumference and waist-to-hip ratio. The multiple linear regression analysis showed there was an independent negative association between secreted frizzled-related protein 5 and homeostasis model assessment of insulin resistance.

Conclusion:

Secreted frizzled-related protein 5 was involved in obstructive sleep apnea and the decrease in secreted frizzled-related protein 5 was directly proportional to the severity of obstructive sleep apnea. There was an independent negative correlation between homeostasis model assessment of insulin resistance and secreted frizzled-related protein 5 in the obstructive sleep apnea group. Secreted frizzled-related protein 5 might be a therapeutic target for insulin resistance in obstructive sleep apnea.
RESUMO
Resumo

Introdução:

A apneia obstrutiva do sono, uma doença comum, é geralmente complicada com resistência à insulina e diabetes melito tipo 2. Acredita-se que a adipocina possa ter um papel importante no desenvolvimento de resistência à insulina e diabetes melito tipo 2 na apneia obstrutiva do sono.

Objetivo:

Avaliar se a proteína secretada relacionada ao receptor frizzled-5, uma nova adipocina, está envolvida em pacientes com apneia obstrutiva do sono não tratada.

Método:

Foram recrutados 76 indivíduos com apneia obstrutiva do sono e 33 indivíduos controle sem apneia obstrutiva do sono e pareados em relação a índice de massa corporal e idade. A concentração plasmática de proteína secretada relacionada ao receptor frizzled-5 foi testada em jejum com o teste Elisa. Além disso, obteve-se correlação entre a proteína secretada relacionada ao receptor frizzled-5 e o modelo de avaliação da homeostase de resistência à insulina. Modelos de análise de regressão linear múltipla com seleção stepwise foram feitos para determinar as associações independentes entre vários fatores e a proteína secretada relacionada ao receptor frizzled-5.

Resultados:

Os níveis plasmáticos de proteína secretada relacionada ao receptor frizzled-5 foram significativamente menores no grupo com apneia obstrutiva do sono do que no grupo controle (grupo com apneia obstrutiva do sono 28,44 ± 13,25 ng/L; grupo controle 34,16 ± 13,51 ng/L; p = 0,023). Além disso, a proteína secretada relacionada ao receptor frizzled-5 foi correlacionada negativamente com o modelo de avaliação da homeostase de resistência à insulina, mas se correlacionou positivamente com a média e a saturação mínima de oxigênio com ou sem ajuste para idade, gênero, índice de massa corporal, circunferência do pescoço, circunferência da cintura e relação cintura-quadril. A análise de regressão linear múltipla mostrou que houve uma associação negativa independente entre a proteína secretada relacionada ao receptor frizzled-5 e o modelo de avaliação da homeostase de resistência à insulina.

Conclusões:

A proteína secretada relacionada ao receptor frizzled-5 esteve envolvida na apneia obstrutiva do sono e sua diminuição foi diretamente proporcional à gravidade da apneia obstrutiva do sono. Houve uma correlação negativa independente entre o modelo de avaliação da homeostase de resistência à insulina e a proteína secretada relacionada ao receptor frizzled-5 no grupo da apneia obstrutiva do sono. A proteína secretada relacionada ao receptor frizzled-5 pode ser um alvo terapêutico para a resistência à insulina na apneia obstrutiva do sono.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Sleep Apnea, Obstructive / Diabetes Mellitus, Type 2 / Eye Proteins / Membrane Proteins Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Friendship Hospital/CN / Capital Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Sleep Apnea, Obstructive / Diabetes Mellitus, Type 2 / Eye Proteins / Membrane Proteins Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Friendship Hospital/CN / Capital Medical University/CN