Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis
Clinics
;
75: e1293, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1055882
ABSTRACT
Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results - Mean difference 95% CI - -0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals -5.05 [-7.68, -2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Physical Conditioning, Animal
/
Ventricular Function
/
Myocardial Infarction
Type of study:
Systematic reviews
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Brazil
/
United kingdom
Institution/Affiliation country:
Centro Universitario Saude ABC/BR
/
Secretaria de Estado da Saude do Acre/BR
/
Universidade Estacio de Sa/BR
/
Universidade Estadual de Sao Paulo (UNESP)/BR
/
Universidade Federal de Sao Paulo/BR
/
Universidade Federal do Espirito Santo/BR
/
Universidade de Sao Paulo/BR
/
University of the West of Scotland/GB
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