Usefulness of aqueous and vitreous humor analysis in infectious uveitis
Clinics
;
75: e1498, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1055886
ABSTRACT
OBJECTIVE:
To evaluate the role of intraocular fluid analysis as a diagnostic aid for uveitis.METHODS:
Twenty-eight samples (27 patients including 3 HIV-infected patients) with active (n=24) or non-active (n=4) uveitis were submitted to aqueous (AH; n=12) or vitreous humor (VH) analysis (n=16). All samples were analyzed by quantitative PCR for herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Toxoplasma gondii.RESULTS:
The positivity of the PCR in AH was 41.7% (5/12), with 50% (2/4) in immunocompetent and 67% (2/3) in HIV+ patients. The positivity of the PCR in VH was 31.2% (5/16), with 13% (1/8) in immunocompetent and 50% (4/8) in immunosuppressed HIV negative patients. The analysis was a determinant in the diagnostic definition in 58% of HA and 50% of VH.CONCLUSION:
Even in posterior uveitis, initial AH analysis may be helpful. A careful formulation of possible clinical diagnosis seems to increase the chance of intraocular sample analysis being meaningful.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aqueous Humor
/
Uveitis
/
Vitreous Body
Type of study:
Evaluation studies
Limits:
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Sao Paulo/BR
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