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Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy
Afkari, Rouhi; Feizabadi, Mohammad Mehdi; Ansari-Moghadam, Alireza; Safari, Tahereh; Bokaeian, Mohammad.
  • Afkari, Rouhi; Zahedan University of Medical Sciences. Resistant Tuberculosis Institute. Infectious Diseases and Tropical Medicine Research Center. Zahedan. IR
  • Feizabadi, Mohammad Mehdi; Tehran University of Medical Sciences. Tehran. IR
  • Ansari-Moghadam, Alireza; Zahedan University of Medical Sciences. Health Promotion Research Center. School of Health. Zahedan. IR
  • Safari, Tahereh; Zahedan University of Medical Sciences. Zahedan. IR
  • Bokaeian, Mohammad; Zahedan University of Medical Sciences. Resistant Tuberculosis Institute. Infectious Diseases and Tropical Medicine Research Center. Zahedan. IR
Int. braz. j. urol ; 45(6): 1249-1259, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1056334
ABSTRACT
ABSTRACT

Objective:

Urinary stones with oxalate composition can cause kidney failure. Recent findings evidenced that probiotics are effective in reducing oxalate absorption in these subjects based on their high colonic absorption levels at baseline. The purpose of this study was to evaluate the effect of the simultaneous use of oxalate-degrading bacteria, Urtica dioica and T. terrestris extract in reducing urinary oxalate. Materials and

Methods:

Anti-urolithiatic activity of Urtica dioica and T. terrestris extract and probiotic by using ethylene glycol induced rat model. In this study, 4 strains of Lactobacillus and 2 strains of Bifidobacterium and also 2 strains of L. paracasei (that showed high power in oxalate degrading in culture media) were used. Male Wistar rats were divided into four groups (n=6). The rats of group-I received normal diet (positive control group) and groups-II (negative control group), III, IV rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Urtica dioica and T. terrestris extract. Groups IV rats received extracts + probiotic for 30 days.

Findings:

The results show that the use of herbal extracts (Urtica dioica and T. terrestris) reduced the level of urinary oxalate and other parameters of urine and serum. Also, the accumulation of calcium oxalate crystals in the kidney tissue was significantly reduced.

Conclusion:

Considering that the formation of calcium oxalate crystals can cause inflammation and tissue damage in the kidney, the use of herbal extracts with oxalate degrading bacteria can be a new therapeutic approach to preventing the formation of kidney stones.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Oxalates / Hyperoxaluria / Plant Extracts / Probiotics / Urtica dioica / Tribulus Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR / Zahedan University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Oxalates / Hyperoxaluria / Plant Extracts / Probiotics / Urtica dioica / Tribulus Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR / Zahedan University of Medical Sciences/IR